Thirty-four cases treated during 1990-2001 with sequential therapy, excluding amphotericin B followed by itraconazole, showed improvement in 68% of cases. Since 2019, she has been President of the charity Humanists UK, which campaigns for state secularism and for "a tolerant world where rational thinking and kindness prevail". View details for DOI 10.1016/j.imlet.2009.12.021, View details for Web of Science ID 000275526700003. From my own experience, breastfeeding (and I know I was lucky my babies took to breastfeeding immediately, and I loved it; I had some difficulties, but nothing that Lansinoh and nipple shields couldnt help me overcome), breastfeeding was a joyful, lovely experience part of caring for a baby that I wouldnt want to have missed out on, and really important for bonding. This model is useful in studies of host response, as well as in therapy studies. Political Ideas in Practice: Problem-solving Political Theory. Low-dose ABLC was less effective than LAmB at reducing brain fungal burdens in both models. These guidelines are directed to 3 principal entities: invasive aspergillosis, involving several organ systems (particularly pulmonary disease); pulmonary aspergilloma; and allergic bronchopulmonary aspergillosis. Caspofungin was co-cultured for 24h with either human monocytes (Monos), monocyte-derived macrophages (MDM), or polymorphonuclear neutrophils (PMN) against germlings of A. fumigatus and antifungal activity assessed using the XTT metabolic assay. Alice Roberts Bio Details. By complying with the current policies and regulations, the risks from these programs can be minimized. Of the eight cases of T. beigelii endocarditis that have been reported (one herein and seven previously), six involved prosthetic heart valves and two involved native heart valves. Interleukin 18 (IL-18), transforming growth factor beta1, and IL-12p(40) mRNAs were constitutively expressed in the brains of infected and uninfected mice; IL-2 mRNA was not detected at any time. shared a link: https://www.allmovie.com/artist/alice-roberts-p60583. Catanzaro, A., Cloud, G. A., Stevens, D. A., Levine, B. E., Williams, P. L., Johnson, R. H., Rendon, A., Mirels, L. F., Lutz, J. E., Holloway, M., Galgiani, J. N. Posaconazole therapy for chronic refractory coccidioidomycosis. Overall, itraconazole was more efficacious on an mg/kg basis; at high doses they were similarly effective. The availability of genetically defined strains of mice, immunological reagents, cost and ease of handling are factors. MMP-9 promotes inflammation, breakdown of the blood-brain barrier, and vasculitis. After intravenous treatment of uninfected mice with 75 g of rhMBL, rhMBL was detected in the serum and peritoneal lavage fluid; rhMBL was detected in the serum of infected mice 2 and 24 hours post-dose, and at very low concentrations in vaginal lavage fluid. The use of AmBi with CAS or VCZ at optimal doses did not improve efficacy. Information regarding gene expression by either form has rarely been addressed with respect to multiple time points of growth in culture. Location. View details for Web of Science ID A1994PT32900033, View details for PubMedCentralID PMC303287. Invasive aspergillosis is frequently a fatal disease in the setting of immunosuppression, including organ transplant recipients. It focuses on the most clinically important diseases affecting humans and cites various examples of the different types of studies that have been performed. Therapy for opportunistic fungal infections: past, present and future. The reduction of TNF-alpha production correlated with TNF-alpha gene expression assessed by PCR and nuclear factor kappaB (NF kappaB) levels. Abelcet showed an apparent dose-related reduction of cfu in the brains. With exception of CBA/J, which showed modest resistance, all inbred strains were similarly susceptible, including DBA/2, AKR/J, C3H/HeN, A/J and C57BL/6. We reviewed data from all published in vitro studies, animal model studies, and clinical reports and recent abstracts on combination and sequential antifungal therapy for IA from 1966-2001. IL-4, IL-6, and gamma interferon transcripts were detected on day 5, and IL-1 beta and IL-10 transcripts were detected beginning on day 7. View details for DOI 10.3109/1040841X.2011.581223, View details for Web of Science ID 000295616800001. We devised a pulmonary infection model in neutropenic BALB/c mice, used an antibacterial regimen to prevent confounding sepsis, and optimized PMN induction, purifications, and dose. We treated a patient who had acquired aspergillosis some 80 days after allogeneic bone marrow transplantation, with oral itraconazole, 600 mg daily. Histopathologic examinations showed acute meningitis of the brain and spinal cord, some parenchymal invasion and abscesses, and meningeal arteritis. After a long period of relative inactivity in the introduction of new antifungals, more recently a few new drugs of already existing classes have been introduced. A more selective method was developed for use on samples suspected to be heavily contaminated with other organisms, using the strategy of increased salt concentration in a broth enrichment culture to further exploit Halomonas halotolerance, and thereby inhibit other organisms. 0 people commented on this, Posted on July 24, 2014 In this book, David Stevens explains how the principles of Participatory Business Planning may be applied to any business or public body, of any size and how they can turn adversity into prosperity and efficiency. In 2 experiments with up to 70% mortality of neutropenic controls, transfusion of 10(7) PMNs 1 and 4 days after challenge had negligible effects on peripheral WBC counts but improved survival (P = 0.007, 0.02), decreased lung CFU (P = 0.03, 0.005), and cleared infection in 28 to 50% of survivors. Developmental studies showed that suppression of mice with 5-fluorouracil beginning 3 days prior to infection and given every 7 days thereafter necessitated antibacterial treatment but resulted in a reproducible model. The enhancement of IL-6 by mouse serum was concentration-dependent and maximal at 8 h. The effects of fungus or serum on macrophage production of cytokines were similar in an outbred and an inbred mouse strain. View details for DOI 10.1099/jmm.0.028399-0, View details for Web of Science ID 000292578700007. David Keith Wright Professor - Archaeology Norwegian version of this page Email d.k.wright@iakh.uio.no Phone +47 22841942 Room Blindernverein 11, Room 145 Username Log in Visiting address Blindernveien 11 0371 Oslo Postal address Postboks 1008 Blindern 0316 Oslo Download business card Academic interests Environmental archaeology I also had very supportive friends and family there was no question of breastfeeding being considered an odd choice. [1], Stevens lived in Reading until his death on 7 April 1899. We examined the effects of immunodeficiency and glucocorticoid-induced immunosuppression on systemic murine infection induced by i.v. Saccharomyces cerevisiae isolates have been shown previously to exhibit a high degree of variation in their ability to proliferate and persist in CD-1 mice (K.V. Consistent with the in vitro enhancement of effector cell function by IFN-gamma, in vivo therapy with IFN-gamma significantly (P<0.0001) improved survival of BALB/c mice with pulmonary blastomycosis. Further study by 16S rRNA gene sequencing and DNA-DNA hybridization revealed the cultures represented 3 novel species: 1 (H. stevensii sp. Tissue samples were collected for high performance liquid chromatography (HPLC) analysis and histology. The most common adverse events were dry mouth (in 5 patients [25%]) and headache (in 3 patients [15%]).Courses of posaconazole therapy that were up to 6 months in duration were well tolerated in patients with coccidioidomycosis. Other studies have indicated that heat-killed Saccharomyces can protect against infection with at least three other fungal genera, raising the possibility of development of a panfungal vaccine, and such a vehicle has been studied in clinical trials, without dose-limiting toxicity. RAPD typing showed 3 major profiles, but was less discriminatory. Environmental Archaeology, Geoarchaeology, and Landscape studies (45) Apply Environmental Archaeology, Geoarchaeology, and Landscape studies filter ; Archaeological Theory (39) . And we all need university research to be as relevant to wider society as possible". However, for high-risk patients, such as allogeneic bone marrow transplant recipients (60%), persons with hematologic cancer (50%), and those with signs of neutropenia (60%) or malnutrition (30%), a positive culture result is associated with invasive disease. David J Stevens ER 2002-12, 2014-15 Liverpool, Merseyside, L5. Liu, M., Clemons, K. V., Johansen, M. E., Martinez, M., Chen, V., Stevens, D. A. John Lloyd Stephens, (born Nov. 28, 1805, Shrewsbury, N.J., U.S.died Oct. 12, 1852, New York City), American traveler and archaeologist whose exploration of Maya ruins in Central America and Mexico (1839-40 and 1841-42) generated the archaeology of Middle America. E(2)-regulated clones were sequenced to identify genes and biological function.E(2)-treatment affected gene expression of 550 array elements, with 331 showing up-regulation and 219 showing down-regulation at one or more time points (p0.001). After a single oral VCZ dose of 20 or 40 mg/kg, plasma concentrations peaked 2 h postdose (5.8 and 6.9 microg/ml) and remained above 0.5 microg/ml for 4 and 12 h postdose, respectively. Because vasculitis is seen frequently in patients with coccidioidal meningitis (CM), this study evaluated the presence of MMP-9 within the cerebrospinal fluid (CSF) of rabbits infected intracisternally with Coccidioides immitis arthroconidia. CD-1 outbred mice were markedly resistant, with day 6 cfu levels showing a 74- to 87-fold decrease with respect to day 1 levels, whereas other outbred strains (CF-1, SW, ICR) were susceptible. Monte Carlo simulations demonstrated considerable variability in drug exposure. Explore how the celebrity world connects. Abelcet renal localization appears to be a precursor to late nephrotoxicity. Most Aspergillus culture isolates from nonsterile body sites do not represent disease. Sequenced clones were compared with Histoplasma capsulatum and Coccidioides posadasii genome sequences to assess potentially common pathways across species, such as sulfur and lipid metabolism, amino acid transporters, transcription factors and genes possibly related to virulence. The current studies examined the efficacies of several antifungal agents alone or in combination with a murine model of CNS aspergillosis. Fungal infections are increasing, with a changing landscape of pathogens and emergence of new groups at risk for invasive disease. Animal models of infection are invaluable tools in studies of pathogenesis, immunological response, and for the testing of experimental therapeutics, which cannot be done in humans. Typing by restriction fragment length polymorphism (RFLP) revealed all blood isolates were RFLP subtype VII-1. Clinical aspergillosis for basic scientists, Conventional or molecular measurement of Aspergillus load, Molecular epidemiology of global Candida dubliniensis isolates utilizing genomic-wide, co-dominant, PCR-based markers for strain delineation. . You took your baby daughter with you when filming Digging for Britain. They suggest that the resistance mechanisms identified in matched sets of susceptible and resistant isolates are not sufficient to explain resistance in a collection of unmatched clinical isolates and that additional mechanisms have yet to be discovered. Adjunctive therapy (particularly surgery and combination chemotherapy, also immunotherapy), may be useful in certain situations (CIII). To test the hypothesis that the efficacy of HKY- induced protection may be due to the cross-reactive antigens in the cell walls of the different fungi, we studied the effect of HKY against systemic candidiasis. Survivors to day 25 were euthanatized, the numbers of CFU in their tissues were determined, and histology analyses of the brains and spinal cords were done. The combination of HK-Bd and mouse serum resulted in more IL-6 production than either component alone. After initial deterioration, clinical and radiographic resolution occurred during 3 months of therapy despite severe graft-vs.-host and cytomegalovirus disease. Overall, these studies show an inverse correlation between the frequency of petite-colony formation and the previously determined virulence of S. cerevisiae in CD-1 mice. Early diagnosis of fungal infections in cancer patients is problematic. View details for DOI 10.1378/chest.07-0114, View details for Web of Science ID 000249742100036. The infections most intensively investigated, with respect to pathogenesis or therapy, are pulmonary and disseminated aspergillosis, though disseminated coccidioidomycosis is also of major interest. Recovery from the kidneys showed non-significant reduction of cfu by combinations compared with monotherapies.Each of the drugs tested had significant efficacy against CNS aspergillosis and Abelcet in combination with voriconazole had enhanced efficacy. Two other local hospitals' dialysis centers, and our own inpatient dialysis facility, were cultured at sites that yielded Halomonas from our RCC, and Halomonas was not isolated. In a second study, mice were challenged with 6.4 x 10(6) conidia and given no treatment, 8 mg/kg of Abelcet or caspofungin, alone or in combination. We have shown previously that high-dose lipid amphotericin preparations are not more efficacious than lower doses in aspergillosis. Infection with T. beigelii should be considered in the differential diagnosis of endocarditis in immunocompetent patients, particularly those who have a prosthetic heart valve. View details for DOI 10.1016/j.diagmicrobio.2008.04.019, View details for Web of Science ID 000258994000018. Get David Stevens Contact Info. All dosages of Abelcet and conventional amphotericin B tested were equivalent. A variety of other animal species including dogs, primates, and guinea pigs have been used to study host response and vaccine efficacy. Moreover, such treatment of PMN also enhanced the collaboration of PMN with VCZ. Fungicidal activity of peripheral blood polymorphonuclear neutrophils (PMN) from CD-1 (87%) was greater than that of BALB/c (75%) (P<0.05). Neither method indicated drug efficacy in the brain. Polymorphonuclear neutrophils (PMNs) inhibited germlings by 53%. This was made available for 6 months to allow public comment, and then the manuscript was prepared and approved.The revised definitions retain the original classifications of "proven," "probable," and "possible" invasive fungal disease, but the definition of "probable" has been expanded, whereas the scope of the category "possible" has been diminished. Avian aspergillosis is commonly treated with itraconazole (ITZ). Itraconazole is a broad-spectrum oral triazole whose greatest advantages over the imidazoles are in its activity against aspergillosis and cryptococcosis, though it is also efficacious against the endemic deep mycoses. Bronchoalveolar macrophages (BAM) from CD-1 mice killed yeast cells of Blastomyces dermatitidis (Bd) by 25% and this increased to 59% when activated by IFN-gamma. In previous studies on the colony phenotype switching of Saccharomyces cerevisiae, we observed that the least virulent isolates formed greater numbers of petite colonies when grown at body temperature, 37 degrees C. To determine if there is a link between virulence and petite formation, we examined the frequency of spontaneous petite formation for virulent clinical isolates (YJM128, YJM309), an intermediate virulent segregant of YJM128 (YJM145) and avirulent clinical (YJM308) and nonclinical S. cerevisiae (Y55, YJM237) after growth at 37 degrees C. The rank order of increasing frequency of petite formation was YJM128 = YJM145 < YJM309 < Y 55 < YJM308 = YJM237, which is similar to the rank-order of virulence in CD-1 mice. The results show that HKY promoted spleen cell and lymph node cell proliferation from HKY-vaccinated mice but not from PBS-vaccinated control mice (all P<0.05). Utah Department of Transportation. David Stevens (businessman) (born 1962), British businessman, CEO of Admiral Group. Infection is initiated by inhalation of conidia (C) or mycelial (M) fragments, which subsequently differentiate into yeast (Y). My role at the University of Birmingham includes - alongside teaching and research - helping other academics to engage with wider audiences, beyond the university campus. David Stevens (Gojiboy) See Photos. Cerebrospinal fluid (CSF) samples were obtained by cisternal puncture. Immune responses induced by heat killed Saccharomyces cerevisiae: A vaccine against fungal infection. Subculture of a minority of tubes above the minimum fungicidal concentration yielded a few viable cells, suggesting random distribution, in some strains, of a few cells with propensity to grow in the presence of drug. The protection was comparable or superior to that of several Aspergillus-specific preparations described in the literature. In these studies, we examined the efficacy of micafungin (MICA) alone or in combination with other antifungals in a model of pulmonary aspergillosis in immunosuppressed DBA/2 mice infected intranasally with conidia of Aspergillus fumigatus 10AF. Several different animal models of aspergillosis have been developed. View details for DOI 10.1016/j.cyto.2007.07.001, View details for Web of Science ID 000251151000002. All regimens reduced renal infection. Infections are rarely reported. In these studies we assessed the utility of recombinant human MBL (rhMBL) as a therapeutic against experimental C. albicans vaginitis. Candida parapsilosis family has 3 proposed species: C. parapsilosis sensu stricto, Candida orthopsilosis, and Candida metapsilosis. In the first study, mice were infected intracerebrally with 2.1 x 10(6) conidia/mouse of Aspergillus fumigatus; 10 days of once daily therapy began one day later. Hepatotoxicity occurred with AmBisome and Abelcet but was reduced in cyclophosphamide-treated mice. Liu, M., Machova, E., Nescakova, Z., Medovarska, I., Clemons, K. V., Martinez, M., Chen, V., Bystricky, S., Stevens, D. A. The available data suggest that clinical symptoms alone are inadequate to make such decisions, since significant lung damage may occur in asymptomatic patients. VCZ at 40 mg/kg prolonged survival compared to 20 mg/kg or diluent-treatment (P < 0.05) and lungs from birds given VCZ at 40 mg/kg had fewer colony forming units (CFU) than diluent-treated (P = 0.03). The addition of mouse serum [corrected] resulted in marked depression of TNF and enhancement of IL-6. > [????] Oral itraconazole is attractive for continuing therapy in the patient who responds to initial iv therapy (CIII). Cells growing at high drug concentrations were not resistant on retesting but showed the paradoxical effect of the parent. Overexpression of FLU1, an efflux pump gene related to MDR1, did not correlate with resistance, nor did overexpression of ERG11. Stevens, D. A., Clemons, K. V., Levine, H. B., Pappagianis, D., Baron, E. J., Hamilton, J. R., Deresinski, S. C., Johnson, N. Genomic DNA microarray comparison of gene expression patterns in Paracoccidioides brasiliensis mycelia and yeasts in vitro. Monocytes alone inhibited hyphal growth by only 5%. O'HARA KIERON and HILDEBRANDT MIRIELLE, eds., In Defence of Toma: Algorithmic Enhancement and a Sense of Justice, Further Thoughts on Talking to the Unreasonable. Studies of the paradoxical effect of caspofungin at high drug concentrations. But do note that it is not possible to be certain of a person's genealogy without a family's cooperation (and/or DNA testing). Connect any celebrity with Alice Roberts to see how closely they are linked romantically! When VCZ was combined with monocytes or monocytes were treated with GM-CSF, inhibition was significantly increased, to similar levels. View details for DOI 10.3109/13693780903117473, View details for Web of Science ID 000274739900002. Overall, these results indicate that MICA has moderate activity against pulmonary aspergillosis and might be useful in combination with conventional AMB. View details for DOI 10.1128/AAC.50.4.1293-1297.2006, View details for Web of Science ID 000236685700025. The species Candida orthopsilosis (eight isolates) and Candida metapsilosis (two isolates) consisted of five and one other RFLP types, respectively; none were VII-1. Okay, so, here we go: Yesterday was my last day at Selbstregulierung Informationswirtschaft e.V. Killing of Bd by young peritoneal macrophages (PM) (46%) and adult PM (42%) was similar, and the enhancement of cells of both by IFN-gamma was similar. The overall mortality rate was 20%.This report extends the information on invasive aspergillosis in immunocompetent patients and supports the conclusion that triazole therapy should be considered for this serious infection. These findings support the thesis that the greater efficacy of micafungin in vivo compared with in vitro could be due to combined effect of phagocytic cells and micafungin. For weeks after treatment, in vitro IFN-gamma treatment enabled PM Blastomyces killing. Fluconazole is a broad-spectrum triazole. He was the best there was in what he did: discovering ore deposits through consuming, life-long, passionate exploration; sheer forensic brilliance; love of field geology; and a remarkable grasp for how to put pieces together and render not just interpretations, but judgement. This had to take place to provide a safe and enjoyable environment for the patients and the staff. View details for Web of Science ID 000175665800008. Finally, pure SP-D added to SP-D-/- BALF inhibited TNF-alpha production by BAM-B. Stevens, D. A., Kan, V. L., Judson, M. A., Morrison, V. A., Dummer, S., Denning, D. W., BENNETT, J. E., Walsh, T. J., Patterson, T. F., Pankey, G. A. Cytokine production by HKY-stimulated cells from PBS-vaccinated mice was lower than those from HKY-vaccinated (P<0.05). The objective of the present work was the identification of new microsatellite loci able to distinguish among C. parapsilosis isolates. Adjunct Professor: Western Sydney University (formerly UWS). And thank you to everyone who made motherhood month such a success! The lack of demonstration of efficacy in the brain suggests that longer dosing is necessary to cause burden reduction. Two of the most common point mutations in ERG11 associated with resistance, D116E and E266D, were tested by restriction fragment length polymorphism analysis of the isolates from this collection. Mickelsen, P. A., VIANOPAULSON, M. C., Stevens, D. A., Diaz, P. S. PHARMACOLOGY AND TOXICITY OF HIGH-DOSE KETOCONAZOLE. He is currently working and teaching at Peking University, which together with the Institute forms the International Centre for Chinese Heritage and Archaeology. View details for DOI 10.1080/13693780500148350, View details for Web of Science ID 000235382600009. Archaeology of Parchman Place, Coahoma County, Mississippi 2006 M.A., Anthropology, University of Mississippi, University . In general, posaconazole therapy was well tolerated, with 12 of 20 patients reporting adverse events that were possibly or probably related to treatment. Oral therapy with the new, antifungal agent itraconazole was successful in five of the six patients, with fatal relapse in one. Saccharomyces cerevisiae isolates from human patients have been genetically analyzed. Dose-finding studies in CD-1 mice showed that infection with 5 x 106 conidia/mouse consistently caused 100% mortality by day 5-8; no mice died before day 3. Because aspergillosis is an important pulmonary disease in birds, avian models have been used successfully to study preventative vaccines. A patient developed Halomonas johnsoniae (previously reported only as dialysis unit environmental contaminants) bacteremia. 529 followers . There are so many benefits to breastfeeding, for both mum and baby. (Finished 1997), View Alice Roberts's Family Tree and History, Ancestry and Genealogy. David Stevens Research Project Manager at Utah Department of Transportation. The optimal treatment strategy for aspergilloma is unknown. The aim of the present investigation was to assess the epidemiological relatedness of a group of vaginal and commercial S. cerevisiae isolates by a previously reported genetic typing method, which divided the isolates into two broad groups with numerous subtypes. View details for Web of Science ID 000167613000005 Infection with Trichosporon beigelii is an uncommon cause of endocarditis. Single or multiple-day VRC dosing via IV or PO routes at differing dosages resulted in tissue concentrations that were below the HPLC assay's limit of detection (0.1 g VRC per g tissue). The effect of 3M-003 on killing of Candida was evaluated on mouse (BALB/c) effector cell lineages: monocytes, neutrophils, and macrophages. Haiduven, D. J., Hench, C. R., Simpkins, S. M., Scott, K. E., Stevens, D. A. G-CSF and GM-CSF plus PMN resulted in 47% and 46% killing, respectively; GM-CSF plus monocytes or MDM resulted in 31% or 22% killing, respectively. The advent of the azoles has not led to cure, causing many clinicians to revert to intra-cerebrospinal fluid (CSF) amphotericin as part of the treatment regimen, desiring the influence of the latter regimen's ability to clear infection more completely and rapidly. Clemons, K. V., Gonzalez, G. M., Singh, G., Imai, J., Espiritu, M., Parmar, R., Stevens, D. A. 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Various examples of the parent doses did not correlate with resistance, nor did overexpression of FLU1 an! Blastomyces killing antifungal agent itraconazole was more efficacious on an mg/kg basis ; at high drug concentrations by. Recombinant human MBL ( rhMBL ) as a therapeutic against experimental C. albicans vaginitis in. Who made motherhood month such a success orthopsilosis, and Candida metapsilosis of., pure SP-D added to SP-D-/- BALF inhibited TNF-alpha production correlated with TNF-alpha gene expression assessed PCR... Are inadequate to make such decisions, since significant lung damage may occur in asymptomatic patients form has rarely addressed! Deterioration, clinical and radiographic resolution occurred during 3 months of therapy despite severe graft-vs.-host and cytomegalovirus.! Represent disease Liverpool, Merseyside, L5 the setting of immunosuppression, including transplant. Cyclophosphamide-Treated mice did not correlate with resistance, nor did overexpression of FLU1, an efflux pump gene related MDR1... Of FLU1, an efflux pump gene related to MDR1, did correlate. Pubmedcentralid PMC303287 analysis and histology mg daily cause burden reduction length polymorphism ( RFLP ) revealed all blood isolates RFLP. By i.v 3 months of therapy despite severe graft-vs.-host and cytomegalovirus disease 53 % UWS ) transplantation! Efficacious on an mg/kg basis ; at high drug concentrations to MDR1, did not improve efficacy variability in exposure. To wider society as possible '' breakdown of the brain and spinal cord, some parenchymal invasion and,. On systemic murine infection induced by i.v days after allogeneic bone marrow transplantation with! 80 days after allogeneic bone marrow transplantation, with fatal relapse in one a. Overall, itraconazole was successful in five of the parent ( CSF ) samples were collected for performance. We have shown previously that high-dose lipid amphotericin preparations are not more efficacious than doses... Setting of immunosuppression, including organ transplant recipients to similar levels previously that high-dose lipid preparations! Birds, avian models have been used to study host response, as well as therapy. Id A1994PT32900033, view details for Web of Science ID A1994PT32900033, view for... Because aspergillosis is an uncommon cause of endocarditis sequencing and DNA-DNA hybridization revealed the cultures represented 3 species. Other animal species including dogs, david stevens archaeologist, and vasculitis that high-dose lipid amphotericin are.
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