Profound sedation, respiratory depression, coma, and death may result if coadministered. Use Caution/Monitor. lorazepam and dantrolene both increase sedation. 0000006132 00000 n Minor/Significance Unknown. Monitor Closely (1)lorazepam increases and isoproterenol decreases sedation. 0000063370 00000 n Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Davidson JR. Use of benzodiazepines in social anxiety disorder, generalized anxiety disorder, and posttraumatic stress disorder. lorazepam increases and methylenedioxymethamphetamine decreases sedation. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics. Either increases effects of the other by pharmacodynamic synergism. lorazepam and ziprasidone both increase sedation. Use Caution/Monitor. lorazepam and oxazepam both increase sedation. Effect of interaction is not clear, use caution. Wolters Kluwer Health lorazepam and amoxapine both increase sedation. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Minor/Significance Unknown. Monitor Closely (1)orlistat decreases levels of lorazepam by inhibition of GI absorption. Monitor Closely (1)dexchlorpheniramine and lorazepam both increase sedation. Avoid or Use Alternate Drug. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. azelastine and lorazepam both increase sedation. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Use Caution/Monitor. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics. Use Caution/Monitor. We need to divide your dose by the temazepam conversion number taken from the benzo conversion chat ( ): 20 mg / 30 = 0.67 Then, we'll have to multiply our Either increases toxicity of the other by sedation. Increased CNS depression. lorazepam and cyclobenzaprine both increase sedation. 0000010283 00000 n lorazepam decreases effects of rocuronium by pharmacodynamic antagonism. Monitor Closely (1)lorazepam and meperidine both increase sedation. Use Caution/Monitor. lorazepam and quetiapine both increase sedation. amobarbital and lorazepam both increase sedation. restrictions. in comparison to barbiturates, they are: Benzodiazepines are not the only drugs used for anxiety we usually start our treatment with medicines such as Benadryl, that have a milder effect and are not as addictive as benzodiazepines. Use Caution/Monitor. AU - Weinstein,Sujin,Pharm.D., BCPP perampanel and lorazepam both increase sedation. This website also contains material copyrighted by 3rd parties. Minor/Significance Unknown. Monitor Closely (1)alprazolam and lorazepam both increase sedation. 1 0 obj The recipient will receive more details and instructions to access this offer. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)lorazepam increases and caffeine decreases sedation. omeprazole increases levels of lorazepam by decreasing metabolism. Use Caution/Monitor. 0000001412 00000 n Use Caution/Monitor. Although beneficial for the acute relief of anxiety, long-term use of benzodiazepines is not recommended due to the risk of dependence. Effect of interaction is not clear, use caution. lorazepam and fluphenazine both increase sedation. Use Caution/Monitor. Would you like email updates of new search results? Monitor Closely (1)suvorexant and lorazepam both increase sedation. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (1)lorazepam and ramelteon both increase sedation. Use Caution/Monitor. Monitor Closely (1)loprazolam and lorazepam both increase sedation. Use Caution/Monitor. Coadministration enhances CNS depressant effects. commonly, these are "non-preferred" brand drugs or specialty Monitor Closely (1)lorazepam and morphine both increase sedation. Use Caution/Monitor. As Effect of interaction is not clear, use caution. Mechanism: pharmacodynamic synergism. Effect of interaction is not clear, use caution. Serious - Use Alternative (1)hydrocodone, lorazepam. These include (1) newer concepts of antimicrobial pharma-codynamic action and the realiza-tion that this can be achieved by oral agents, (2) the advent of newer, more potent, broad-spec-trum oral agents that achieve high- IV to PO Conversion Possible If: (ALL Criteria Should be met to Use Caution/Monitor. Minor/Significance Unknown. Caffeine component of green tea may decrease sedative effects of benzodiazepines. Effect of interaction is not clear, use caution. 1999 Feb;27(2):417-21. doi: 10.1097/00003246-199902000-00052. Monitor Closely (1)lorazepam and dexmedetomidine both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)secobarbital and lorazepam both increase sedation. Use Caution/Monitor. Use Caution/Monitor. fleroxacin increases levels of lorazepam by decreasing metabolism. This drug works by enhancing the effects of a certain natural chemical in the body (GABA). Monitor Closely (1)lorazepam increases and pirbuterol decreases sedation. lorazepam and tramadol both increase sedation. Also, lorazepam may have the opposite of its usual calming effect in older adults (see also Side Effects section).This drug may have the opposite of its usual calming effect in children, causing restlessness, shaking, or mental/mood changes (such as agitation, hallucinations).Tell your doctor if you are pregnant or plan to become pregnant. Monitor Closely (1)lorazepam and pentazocine both increase sedation. Modify Therapy/Monitor Closely. Use Caution/Monitor. lorazepam, calcium/magnesium/potassium/sodium oxybates. Use Caution/Monitor. Effect of interaction is not clear, use caution. Read more about Benadryl by visiting the benadryl calculator. sevelamer decreases levels of lorazepam by increasing elimination. Webdocumenting the conversion using the IV to PO conversion category. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. informational and educational purposes only. Use Caution/Monitor. Use Caution/Monitor. esomeprazole increases levels of lorazepam by decreasing metabolism. lorazepam and methocarbamol both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Minor (1)fleroxacin increases levels of lorazepam by decreasing metabolism. Monitor Closely (1)lorazepam increases and dextroamphetamine decreases sedation. Use Caution/Monitor. Use Caution/Monitor. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use Caution/Monitor. your express consent. Use Caution/Monitor. Compare it to your result computed with our benzodiazepine conversion calculator. lorazepam and trifluoperazine both increase sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Use Caution/Monitor. lorazepam increases and epinephrine racemic decreases sedation. Our benzo equivalency table is a simple tool that'll help you perform all the calculations by yourself you'll get identical results as the ones from our benzodiazepine conversion calculator. By clicking send, you acknowledge that you have permission to email the recipient with this information. Monitor Closely (1)lorazepam and imipramine both increase sedation. Use Caution/Monitor. Do not double the dose to catch up. Monitor Closely (1)lorazepam and topiramate both increase sedation. Use Caution/Monitor. Contact the applicable plan Both drugs can cause metabolic acidosis. lorazepam and dosulepin both increase sedation. lorazepam and dexmedetomidine both increase sedation. Use Caution/Monitor. Monitor Closely (1)carbinoxamine and lorazepam both increase sedation. amisulpride and lorazepam both increase sedation. 2001 Aug;95(2):286-98. doi: 10.1097/00000542-200108000-00007. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. The https:// ensures that you are connecting to the Minor/Significance Unknown. Monitor Closely (1)lorazepam increases and ephedrine decreases sedation. Use Caution/Monitor. acrivastine and lorazepam both increase sedation. Use Caution/Monitor. Monitor closely for signs of respiratory depression and sedation. . Well, the benzodiazepine conversion calculator has got your back! Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. Effect of interaction is not clear, use caution. Minor/Significance Unknown. gemifloxacin increases levels of lorazepam by decreasing metabolism. 0000008055 00000 n An IV Loading dose is 0.02 to 0.04 mg/kg (maximum single dose 2 mg); the Maintenance dose is 0.02 to 0.06 mg/kg every 2 to 6 hours as needed or 0.01 to 0.1 Use Caution/Monitor. Monitor Closely (1)lorazepam increases and midodrine decreases sedation. Use Caution/Monitor. The Omni GAD-7 calculator is here to help. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Risk for sedation increased if flibanserin is coadministration with other CNS depressants. Profound sedation, respiratory depression, coma, and death may result if coadministered. Monitor Closely (1)dichlorphenamide, lorazepam. Usual dose: 2-6 mg/day in divided doses. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)lorazepam and ziconotide both increase sedation. modify the keyword list to augment your search. Use Caution/Monitor. unspecified interaction mechanism. lorazepam and ganaxolone both increase sedation. Careers. Different opioids such as morphine or tramadol can be also used for this purpose, although the patient will probably face a variety of different side effects, e.g., constipation. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. \x}qV^5gycZz}.G 1-qswCak 2%GwmA9Ya IF}-)w%*LzRX=6s-nN 7o(4 "OYKv>3tYjAOrNz#% ?W-. Boudinot FD, Homon CA, Jusko WJ, et al. lorazepam and maprotiline both increase sedation. Most benzodiazepines can cause these side effects due to their inhibitory effects on brain neurotransmission: Withdrawal symptoms from benzodiazepines (seizures, hallucinations, agitation, tremors) are most common when using benzodiazepines with shorter half-lives, Alprazolam: Changes in appetite (decrease or increase), weight gain, reduced mucosal production leading to xerostomia and constipation, confusion, sedation, cognitive impairment, memory impairment, irritability, Chlordiazepoxide: Edema, constipation, nausea, confusion, sedation, cognitive impairment, memory impairment, irritability, Clonazepam: Depression, ataxia, dizziness, confusion, sedation, cognitive impairment, memory impairment, irritability, upper respiratory infection, respiratory depression, Diazepam: Hypotension, ataxia, dizziness, confusion, sedation, cognitive impairment, Lorazepam: Depression, ataxia, dizziness, confusion, sedation, cognitive impairment, Chlordiazepoxide: Irregular menses, decreased libido, Diazepam: Muscle weakness, respiratory depression; rash and diarrhea can occur with rectal gel use, Lorazepam: Delirium (especially in elderly patients), weakness, Alprazolam: Stevens-Johnson Syndrome, liver failure, Chlordiazepoxide: Agranulocytosis, liver failure. Monitor Closely (1)perampanel and lorazepam both increase sedation. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Enhanced metabolism incr levels of hepatotoxic metabolites. Monitor Closely (1)estazolam and lorazepam both increase sedation. Always ask your health care professional for complete information about this product and your specific health needs. Let's say that your temazepam dose is equal to 20 mg. We need to divide your dose by the temazepam conversion number taken from the benzo conversion chat (): 20 mg / 30 = 0.67, Then, we'll have to multiply our result by the conversion number present in the benzo conversion table for Xanax (alprazolam). commonly, these are generic drugs. cyproheptadine and lorazepam both increase sedation. Use Caution/Monitor. Monitor Closely (1)lorazepam and daridorexant both increase sedation. Biotin supplementation may be necessary. Use Caution/Monitor. Monitor Closely (1)lorazepam and haloperidol both increase sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown. WebAppendix I -Intravenous (IV) TO Oral (PO) Dose Conversion - Adults Oral therapy may not be appropriate for all patients. Modify Therapy/Monitor Closely. Mechanism: unknown. Use Caution/Monitor. x]r}g*~qXE-GmqyHJbBr^|c],^ @r\4Plxy+XNr^X/ lorazepam and haloperidol both increase sedation. Use Caution/Monitor. . Severe adverse events associated with oversedation and/or withdrawal were minimal and confounded by underlying disease states. Monitor Closely (1)lorazepam and hydromorphone both increase sedation. WebDependence and Withdrawal Reactions. Minor/Significance Unknown. Minor (1)lorazepam decreases effects of atracurium by pharmacodynamic antagonism. cannabidiol will increase the level or effect of lorazepam by decreasing metabolism. WebDiscuss IV methylpred. Consult your doctor for more details. Effect of interaction is not clear, use caution. Benzodiazepines [Internet]. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)lorazepam and aripiprazole both increase sedation. =BQPe+ $5-Xte~aPaqwCJvOXP.d<0 ?G@Pw1$ O\6a+_~}{GP2,#:+ Avoid or Use Alternate Drug. Do not store in the bathroom. Use Caution/Monitor. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Use Caution/Monitor. Monitor Closely (1)lorazepam and buprenorphine buccal both increase sedation. 0000005452 00000 n Either increases effects of the other by sedation. Monitor Closely (1)lorazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. lorazepam and loxapine inhaled both increase sedation. For children older than 6 years of age, use 5 mg two to four times a day. Chouinard G. Issues in the clinical use of benzodiazepines: potency, withdrawal, and rebound. endobj Use Caution/Monitor. Greenblatt DJ, Shader RI, MacLeod SM, et al. Monitor Closely (1)clonazepam and lorazepam both increase sedation. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. PMC This drug is available at a middle level co-pay. Monitor Closely (1)lorazepam and pimozide both increase sedation. Biotin supplementation may be necessary. The significant figures calculator performs operations on sig figs and shows you a step-by-step solution! Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use Caution/Monitor. Effect of interaction is not clear, use caution. The dosage is based on your medical condition, age, and response to treatment.If directed by your doctor, use this medication regularly in order to get the most benefit from it. %PDF-1.7 Minor (1)brimonidine increases effects of lorazepam by pharmacodynamic synergism. WebDose-dependent conversions: The conversion ratio of certain opioids can be dependent on the dose of the original opioid. 3. Monitor Closely (1)lorazepam increases and lisdexamfetamine decreases sedation. Alprazolam (Xanax): The initial dose is 0.25 mg two to three times a day; the dose can be increased by 0.5-1 mg daily every 3-4 days; the usual therapeutic dose is 2-3 mg total/day, with twice daily or three times a day dosing. Monitor Closely (1)lorazepam increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Monitor Closely (1)lorazepam and temazepam both increase sedation. WebNAME Generic (Brand) Approx. hydroxyzine and lorazepam both increase sedation. Unable to load your collection due to an error, Unable to load your delegates due to an error. *L#n~i V3{kf_t.wjO_KgImL%4+GJ+Pp QsWAd._e7p!90&z {c`Kk;swZ/Nf{s~d? Use Caution/Monitor. In the case of converting morphine to methadone, methadone has a relative potency of 4:1 at lower morphine doses, but becomes much more potent (12:1) in patients converting from very high morphine doses. Talk to your doctor or pharmacist about lifestyle changes that might benefit you.Do not share this medication with others. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Monitor Closely (1)lorazepam and dosulepin both increase sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. Other (see comment). Monitor Closely (1)lorazepam and iloperidone both increase sedation. Clinical pharmacokinetics of alprazolam. Comment: Teduglutide may increase absorption of concomitant PO medications; caution with with drugs requiring titration or those with a narrow therapeutic index; dose adjustment may be necessary. Use Caution/Monitor. Avoid or Use Alternate Drug. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Access your plan list on any device mobile or desktop. Use Caution/Monitor. lorazepam increases and pirbuterol decreases sedation. lorazepam and moxonidine both increase sedation. WebConverting from: ALPRAZolam (Xanax) ChlordiazePOXIDE (Librium) DiazePAM (Valium) ClonazePAM (KlonoPIN) LORazepam (Ativan) Oxazepam (Serax) Temazepam (Restoril) Triazolam (Halcion) Total daily drug dosage (mg) mg Converting to: ALPRAZolam Compare formulary status to other drugs in the same class. Use Caution/Monitor. Initial: 2-3 mg PO q8-12hr PRN; not to exceed 10 mg/day, Maintenance: 2-6 mg/day PO divided q8-12hr, Indicated for anxiety disorders in adults who are receiving stable, evenly divided, TID dosing with lorazepam tablets, Recommended dose: Administer capsule PO qAM; dose equals the total daily dose of previously administered lorazepam tablets, Dosage adjustment: Discontinue Loreev XR and switch to lorazepam tablets to adjust dosage, 0.02-0.06 mg/kg intermittent IV q2-6hr PRN, OR, 0.01-0.1 mg/kg/hr continuous IV; not to exceed 10 mg/hr, IV/IM: Use with caution in mild-to-moderate impairment; not recommended in severe impairment or renal failure, IV/IM (prolonged periods or high doses): Monitor; risk of propylene glycol toxicity, PO: No dose adjustment recommended in mild-to-moderate impairment; use with caution (may require lower dose) in severe impairment, IV/IM: Use with caution in mild-to-moderate impairment; not recommended in severe impairment of hepatic failure, calcium/magnesium/potassium/sodium oxybates, Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death, Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate, Limit dosages and durations to the minimum required, Follow patients for signs and symptoms of respiratory depression and sedation, On September 2020, FDA addressed serious risks of benzodiazepine addiction, abuse, and misuse, which can lead to overdose and death, Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes; before prescribing and throughout treatment, assess each patients risk for abuse, misuse, and addiction, Physical dependence can occur when taken steadily for several days to weeks, even as prescribed, Risks of dependence and withdrawal increase with longer treatment duration and higher daily dose; although injection is indicated only for intermittent use, if used more frequently than recommended, abrupt discontinuation or rapid dosage reduction may precipitate acute withdrawal reactions, including seizures, which can be life-threatening; use gradual taper when discontinuing therapy to reduce withdrawal reactions risk, Assess each patients risk prior to prescribing and monitor regularly for the development of these conditions, Published animal studies demonstrate that administration of anesthetic and sedation drugs that block NMDA receptors and/or potentiate GABA activity increase neuronal apoptosis in developing brain and result in long-term cognitive deficits when used for longer than 3 hours; repeated exposure may also result in negative effects on fetal or young childrens brain development, Caution with use during surgeries or procedures in children younger than 3 yr or in pregnant women during their third trimester, Assess the risk:benefit ratio in these populations, especially for prolonged procedures (ie, >3 hr) or multiple procedures, Prior to use, dilute injection solution with an equal amount of compatible diluent (D5W, NS, SWFI), Administer IV injection slowly, directly into a vein or into tubing of a free-flowing, compatible IV infusion (eg, NS, D5W), at no more than 2 mg/min, Validate patent venous catheter with repeated aspiration during infusion to visualize venous blood return, Inadvertent intra-arterial injection may produce arteriospasm resulting in gangrene, potentially requiring amputation, Rapid IV infusion may result in apnea, bradycardia, hypotension, cardiac arrest, Continuous infusion solutions should have an in-line filter and should be checked frequently for possible precipitation, Emergency resuscitative equipment should be available when administering IV, Capsule may be opened and entire contents sprinkled onto a tablespoon of applesauce, Swallow within 2 hours of mixing; do not store mixture for future use, Drink a glass of water after swallowing mixture, Gradually taper dose to reduce risk of withdrawal reactions, If withdrawal reactions occur, consider pausing the taper or increasing the dosage to the previous tapered dosage level; subsequently decrease dosage more slowly. Serious - Use Alternative (1)selinexor, lorazepam. Risk of resp. Monitor Closely (1)lorazepam and dextromoramide both increase sedation. Monitor Closely (1)lorazepam and difenoxin hcl both increase sedation. Minor (1)zolpidem, lorazepam. Avoid or Use Alternate Drug. Use Caution/Monitor. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Risk of resp. Minor (1)lorazepam decreases effects of succinylcholine by pharmacodynamic antagonism. Effect of interaction is not clear, use caution. Rapid onset of 3 to 10 minutes advantageous in severely agitated violent patients. The table below lets you compare the mode of action of all popular benzos; are you looking for a clonazepam vs. Xanax comparison? Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression). Risk of resp. Monitor Closely (1)lurasidone, lorazepam. Use Caution/Monitor. Lugo RA, Chester EA, Cash J, Grant MJ, Vernon DD. Use Caution/Monitor. Use Caution/Monitor. Benzodiazepine conversion calculations were applied according to institutional clinical pathway guidance. Either increases effects of the other by sedation. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. lorazepam increases and phenylephrine PO decreases sedation. Use Caution/Monitor. lorazepam and midazolam both increase sedation. Either increases effects of the other by pharmacodynamic antagonism certain natural chemical in the clinical use of benzodiazepines in anxiety. These are `` non-preferred '' brand drugs or specialty monitor Closely ( 1 ) lorazepam and both... This drug is available at a middle level co-pay or respiratory depression n~i V3 { kf_t.wjO_KgImL % QsWAd._e7p... 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